Regenerating the Injured Brain
Stem cell therapy offers a new frontier for Cerebral Palsy (CP) by addressing the underlying neural damage, promoting myelin repair, and restoring function.
How Stem Cells Work in CP
The Repair Process
In CP, brain injury (often hypoxic-ischemic) leads to the loss of pre-myelinating oligodendrocytes (pre-OLs), causing white matter damage (PVL) and motor deficits.
Replenishing Cells
Stem cells differentiate into new pre-OLs and mature oligodendrocytes.
Remyelination
New oligodendrocytes restore myelin sheaths around damaged axons, improving signal transmission.
Neuroprotection
Secretion of anti-inflammatory cytokines (IL-10) reduces toxic inflammation (TNF-α, IL-1β) and promotes endogenous repair.
Angiogenesis & Homing
Stem cells have a unique "homing" ability, migrating to sites of injury to initiating repair.
- Reperfusion: Formation of new blood vessels reverses hypoxia.
- Trophic Support: Release of BDNF, VEGF, and NGF supports neuron survival.
- Plasticity: Encourages the formation of new neural connections.
Clinical Evidence: Sharma et al. Study
An analysis of 40 CP patients (11 Diplegic, 23 Quadriplegic, 6 Miscellaneous) treated with autologous bone marrow mononuclear cells.
Improvements in Diplegic CP Patients (N=11)
Key Improvements (Diplegic CP)
- 100% Improved Sitting Balance
- 90.9% Improved Standing/Walking
- 90% Improved Hand Function
- 83% Improved Oromotor Skills
- 80% Improved Cognition
- 66.7% Improved Speech
Key Improvements (Quadriplegic CP)
- 83% Improved Neck Holding
- 79% Improved Sitting Balance
- 63% Improved Cognition
- 60% Improved Oromotor Skills
- 54.5% Improved Ambulation
- 45.4% Improved Speech
Improvements in Quadriplegic CP Patients (N=23)
Overall, 95% of patients showed symptomatic improvements.
Large Scale Efficacy (N=193)
In a larger analysis of 193 CP patients, outcomes were graded based on the number of symptoms improved.
91.7%
Overall Improvement
31%
Mild Improvement
47%
Moderate Improvement
13.5%
Significant Improvement
Objective Proof: PET-CT Scans
Before Therapy
Scans show significant hypometabolism (reduced function) in key motor and cognitive areas:
- Motor Cortex
- Basal Ganglia
- Thalamus
- Cerebellum
- Mesial Temporal Structures
After Therapy (6 Months)
Scans reveal increased metabolic activity (green/orange areas) correlating with functional gains in:
- Fine Motor Skills
- Gait & Balance
- Speech & Cognition
- Reduced Spasticity
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The health and medical information provided on this website is for general educational and informational purposes only.
Not Medical Advice: This information is not intended as a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or another qualified health provider with any questions you may have regarding a medical condition. Never disregard professional medical advice or delay in seeking it because of something you have read on WHOLE BODY website. No physician-patient relationship is created by this web site or its use.
FDA Statement: Statements and products mentioned on this site have not been evaluated by the Food and Drug Administration (FDA). The information including any discussed therapies or products are not intended to diagnose, treat, cure, or prevent any disease or medical condition.
User Responsibility: You should not use the information on this website for self-diagnosis or to delay seeking professional medical care. Reliance on any information provided by this website is solely at your own risk.
Medical Disclaimer
The health and medical information provided on this website is for general educational and informational purposes only.
Not Medical Advice: This information is not intended as a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or another qualified health provider with any questions you may have regarding a medical condition. Never disregard professional medical advice or delay in seeking it because of something you have read on WHOLE BODY website. No physician-patient relationship is created by this web site or its use.
FDA Statement: Statements and products mentioned on this site have not been evaluated by the Food and Drug Administration (FDA). The information including any discussed therapies or products are not intended to diagnose, treat, cure, or prevent any disease or medical condition.
User Responsibility: You should not use the information on this website for self-diagnosis or to delay seeking professional medical care. Reliance on any information provided by this website is solely at your own risk.
