Beyond the Modulators
While new drugs have extended life expectancy, MSCs are the next frontier: a "Medicinal Signaling Cell" capable of resolving the persistent triad of infection, inflammation, and tissue damage.
The Changing Face of CF
Advances in care have pushed survival into the 4th and 5th decades. However, as patients live longer, they face new challenges that small molecules alone cannot solve.
Current Therapy Limitations
Some patients are ineligible or intolerant to modulators.
Persistent Inflammation
Chronic immune dysregulation continues to damage organs.
Resistant Infections
Traditional antibiotics struggle against CF-specific biofilms.
The MSC "Drug Store"
MSCs are not just structural building blocks; they are living factories that sense the environment and secrete powerful bio-active factors to heal the CF lung.
Antimicrobial Power
MSCs secrete Antimicrobial Peptides (AMPs) that directly kill bacteria and make them more sensitive to antibiotics.
Key Agents:
- • Cathelicidin (LL-37)
- • Beta-Defensin 2
- • Hepcidin
Inflammation Resolution
MSCs reprogram the immune system, shifting it from a destructive "chronic" state to a healing state.
Key Mechanisms:
- • IL-10 Secretion
- • Extracellular Vesicles (EVs)
- • Macrophage Reprogramming
Multi-Organ Repair
Beyond the lungs, MSCs address the systemic complications of aging with Cystic Fibrosis.
Targets:
- • CF-Related Diabetes
- • Liver Disease
- • Gastrointestinal Health
Clearing the Infection
In vitro studies confirm that MSCs possess potent antimicrobial activity against the specific, difficult-to-treat pathogens that colonize CF patients.
Proven Activity Against:
- Pseudomonas aeruginosa
- Staphylococcus aureus (MRSA)
- Mycobacterium abscessus
- Streptococcus pneumoniae
"First in CF" Clinical Success
Phase I Trial (CEASE CF)
We conducted the first clinical trial using Allogeneic Bone Marrow MSCs in CF patients.
15
Patients Treated
100%
Safety Profile
Safe
Single Infusion
The Path to Phase II
Building on safety data, the next phase focuses on optimizing the MSC product to maximize Antimicrobial and Anti-inflammatory potency for enhanced clinical efficacy.
Medical Disclaimer
The health and medical information provided on this website is for general educational and informational purposes only.
Not Medical Advice: This information is not intended as a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or another qualified health provider with any questions you may have regarding a medical condition. Never disregard professional medical advice or delay in seeking it because of something you have read on WHOLE BODY website. No physician-patient relationship is created by this web site or its use.
FDA Statement: Statements and products mentioned on this site have not been evaluated by the Food and Drug Administration (FDA). The information including any discussed therapies or products are not intended to diagnose, treat, cure, or prevent any disease or medical condition.
User Responsibility: You should not use the information on this website for self-diagnosis or to delay seeking professional medical care. Reliance on any information provided by this website is solely at your own risk.
Medical Disclaimer
The health and medical information provided on this website is for general educational and informational purposes only.
Not Medical Advice: This information is not intended as a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or another qualified health provider with any questions you may have regarding a medical condition. Never disregard professional medical advice or delay in seeking it because of something you have read on WHOLE BODY website. No physician-patient relationship is created by this web site or its use.
FDA Statement: Statements and products mentioned on this site have not been evaluated by the Food and Drug Administration (FDA). The information including any discussed therapies or products are not intended to diagnose, treat, cure, or prevent any disease or medical condition.
User Responsibility: You should not use the information on this website for self-diagnosis or to delay seeking professional medical care. Reliance on any information provided by this website is solely at your own risk.
